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Tirzepatide is a pivotal therapeutic option for type 2 diabetes management, chronic weight management in adults with obesity or overweight with weight-related comorbidities, and treatment of moderate to severe obstructive sleep apnea in obese adults, leveraging its dual GLP-1 and GIP receptor agonism to achieve superior glycemic control and weight reduction

Perfused upper small intestine Male mice ( n = 6) were anaesthetised as described above, and the upper small intestine was isolated and perfused as previously described [23]