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PMCID: PMC3175396

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In mouse models of diseases such as ALI, liver fibrosis, NAFLD, and NASH, treatment with lipophilic antioxidants was shown to prevent disease progression and extend life expectancy

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63 The expression of MTHFD2 is closely related to the response of the folate antagonist methotrexate (MTX) and the thymidylate synthase inhibitor pemetrexed