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Not a single-target drug that hammers one pathway and creates side effects elsewhere, but multi-mechanism molecules that can address inflammation, barrier repair, and microbial defense at the same time
Turkiewicz, A., Kiadaliri, A
COA and Research-Material Quality Control COA Boundary Statement: Certificate-of-analysis data are batch-specific laboratory raw-material quality-control information only
Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis