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This finding implies that the NHP model can be effectively employed to evaluate novel therapeutic approaches for these conditions

The higher complexity of human thinking and emotions compared to other species, as well as the similarity between non-human primate brains and those of humans in comparison to rodents, necessitate further preclinical studies involving higher animals to validate the alleviating and therapeutic effects of polysaccharides on depression

56,57 In line with the literatures, our data showed that the expression of autophagy-related proteins LC3II/I and Beclin1 decreased and the expression of autophagy substrate p62 increased after semaglutide treatment

These may include injection-site redness or minor irritation following subcutaneous administration

Step 1: ring opening The furanose ring of ribose 5-phosphate is opened by interaction with an aspartic acid residue (Asp 81 ), which accepts a proton from the hydroxyl group bound to C-1