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Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults

Observed findings depend on route, formulation, concentration, and study design

Its primary function is in tissue repair: it promotes actin polymerization (required for cell movement), upregulates anti-inflammatory proteins, and stimulates the migration of keratinocytes and endothelial cells that are needed to close and repair damaged tissue

Further mechanistic studies revealed that EGCG-Zn achieves synergistic anti-inflammatory and repair effects by inhibiting MAPK signaling-mediated inflammation and apoptosis, and by activating the Rap1 pathway, which regulates mucosal barrier repair

Microarray slides were scanned using an Agilent G2565A DNA Microarray Scanner, and image analysis was performed using the Feature Extraction V10.10.1.1 software (Agilent Technologies)