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K.Smith-ByrneK.et al (2020)

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BMC Musculoskelet Disord

Activated mutant FGFR3 (aFGFR3) upregulates the expression of key SSP enzymes such as PHGDH and PSAT1 through downstream signaling pathways, promoting intracellular de novo serine synthesis in bladder cancer cells ( Specifically, elevated serine synthesis subsequently activates the PI3K/Akt pathway in tumor-associated macrophages, shifting macrophages toward an immune-inert phenotype