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The debilitating, slow damage created by high levels of blood sugar (glucose) destroys everything from your blood vessels to your eyes, kidneys, and nerves over time due to oxidative stress (remember the free radicals or reactive oxygen species (ROS)?)

Starting earlier could interfere with the natural weight loss phase from surgery and make it harder to distinguish surgical effects from medication effects

Our findings support this hypothesis, as increases in vitamin D and reductions in cortisol and CRP persisted after weight adjustment, whereas changes in glucose, HbA1c, insulin, HOMA-IR, HDL, and other metabolic markers appeared to be predominantly mediated by weight loss.12,28,29 In 2017, the first case was published describing a patient with refractory HS, obesity, and type 2 diabetes who experienced improvement in dermatologic lesions following treatment with liraglutide.19 Subsequent prospective case series further explored this therapeutic strategy, although these cohorts consistently included patients with type 2 diabetes, and liraglutide doses were therefore lower than those approved for obesity management

Across all STEP trials, the consistent finding was 14.9% to 17.4% average body weight reduction at 68 weeks with the 2.4 mg dose

If you continue to feel drained or notice that fatigue interferes with daily activities, its a good idea to check with a healthcare provider