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A study examined the use of GLP-1 receptor agonists (GLP-1 RAs) in the UK from 2009 to 2017, finding that 45% of the 589 patients initiating GLP-1 RA therapy discontinued within 12 months, with 65% discontinuing within 24 months

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Simultaneously, PCs stimulate AMPK, which increases eNOS levels and nitric oxide production, thereby enhancing vascular endothelial performance (Cui et al., 2012)