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The combination shows approximately 15-18% weight loss, falling between semaglutide alone and tirzepatide

In peripheral nerves, the preferential effect on small, myelinated fibers accounts for the characteristic order of sensory loss (pain, temperature, touch, proprioception) followed by motor blockade

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Dinh Tran, MD

Occasional reports include constipation, vomiting, or abdominal discomfort, typically resolving as tolerance develops