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For people on GLP-1 medications, soluble prebiotic fiber is generally considered gentler than insoluble fiber, particularly during periods of slower gastric motility

Understanding these differences is essential for selecting an appropriate supplement, particularly for patients experiencing gastrointestinal symptoms from GLP-1 therapy

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

Additionally, in GLP-1R and GIPR, K/R 2.67b and R299 GLP-1R /R289 GIPR in ECL2 form two hydrogen bonds with T7 P and S11 P , respectively