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It was demonstrated that 4 weeks of resistance exercise intervention significantly upregulated the mRNA and protein expression of Irisin and Fibronectin type III domain containing 5 (FNDC5) in the hearts of mice with MI, increased AMPK phosphorylation and SOD2 expression, promoted PINK1 and Parkin protein expression, and decreased p62 protein level, which subsequently promoted PINK1/Parkin-mediated mitophagy, inhibited OS, decreased myocardial LVIDs and LVIDD, increased the ejection fraction (EF) and the shortening fraction of the left ventricle (FS), and improved the cardiac function of mice

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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Ryad N.M., Ramadan E.S., Salem N.Y., Saleh I.A.E.-S

What we've seen is that the overall incidence of adverse effects with IV Therapy is exceedingly low

Al'miasheva, M