586 This study was designed to characterize the kinetics of chloral hydrate (CH) metabolism, and the formation and elimination of trichloroacetate (TCA), dichloroacetate (DCA), trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) in male B6C3F1 mice
Apovian, MD, co-director of the Center for Weight Management and Wellness in the division of endocrinology, diabetes and hypertension at Brigham and Womens Hospital and a Healio | Endocrine Today Editorial Board Member, said much of the concern surrounding compounded medications revolves around the difference in how the FDA regulates them compared with agents from pharmaceutical companies
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One notable target is cyclin-dependent kinase 12 (CDK12), whose inhibition has demonstrated efficacy against Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)
