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Similarly, the accumulation of fumarate is generally caused by loss-of-function mutations of the relative enzyme FH, which converts fumarate into malate, and these mutations have been evidenced mainly in neuroblastoma and glioblastoma [24]

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A recent study has suggested that androgen binding induces a switch that exposes the NLS and thereby allows the NLS to promote nuclear import through binding of importin- 53

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