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The enzyme recognizes alanine at position 8 as a cleavage site and cuts the peptide chain right there, rendering the hormone inactive within minutes

NIDDK notes that these medications reduce appetite and slow gastric emptying, which together can support clinically meaningful weight reduction

This is where most people leave results on the table

This doesnt necessarily mean GLP-1s are bad, but there is a chance that future safety concerns will surface

In the last 20 years, the emergence of pharmacological treatments for obesity based on gastrointestinal hormones has transformed the therapeutic landscape