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A 2023 retrospective cohort analysis in JAMA Internal Medicine (N=16,922) found that patients on a GLP-1 RA plus an opioid had a 33% higher rate of bowel obstruction-related ED visits compared to patients on a GLP-1 RA alone [5]

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Step 4: Maintenance and cycling (ongoing) After your initial 6-8 week cycle, take 2-4 weeks off completely

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