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Conclusions We found no signal of disproportionate reporting of an association between GLP-1RA use and SSIBs

As a result, we have seen changes in recommendations for these GLP-1s from second-line to first-line treatment in the ADA Standards of Care in Diabetes 2023 and updates to the ACC 2020 Guidelines for Novel Cardiovascular Risk Reduction in Patients with T2D

The hit wasn't evenly distributed even in that first wave

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Men trying to conceive can generally continue GLP-1 RA therapy if needed for their health, but its reasonable to have a discussion about the limited data and perhaps perform baseline and follow-up semen analyses