Effects on gastric emptying are significant and appear to lessen with long-term use, possibly due to tachyphylaxis of vagal nerve activation
Recent Trends: Emerging trends include integration with digital health platforms, development of combination therapies, precision medicine approaches, emergence of biosimilars, and long-acting formulations
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The most common retatrutide side effects at the 12mg dose are nausea (28%), diarrhea (24%), constipation (21%), and vomiting (17%)
Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine , Massachusetts Medical Society, 2021