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In addition, NMDAR has intrinsic modulatory sites that are active targets for drug development, several of which show promise in preclinical/early clinical trials targeting both symptoms and cognition

Materials and Methods Isolation and in vitro Expansion of Human Chondrocytes Human chondrocytes were isolated from de-identified knee articular cartilage without signs of osteoarthritis or injury

It should be noted that most preclinical works explore TBI ketometabolism through nutritional supplementation and do not directly assess endogenous ketones in TBI pathology

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Furthermore, we found that spatial discrimination and reversal learning scores correlate with mRNA and miRNA transcription levels in mPFC