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They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

For instance, in February 2024, the Ministry of Health, Canada, introduced Bill C-64 to establish universal pharmacare, covering diabetes drug such as insulin USD 900-USD 1,700/year, metformin ~USD 100/year, and adjunct therapies USD 100-USD 1,000+/year for type 1 and type 2 diabetes patients under single-payer insurance