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preferential signalling of ligands through one or the other of these branches is known as ligand bias

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CC: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing

GLP-1 medications typically produce greater triglyceride reductions (10-25%) compared to LDL changes (variable 5-15%)

To investigate glucose levels and GLUD1 regulation, we established glucose concentration gradients and observed that high glucose destabilized GLUD1 by inhibiting the PI3K/AKT pathway, whereas glucose downregulation, achieved by insulin or metformin treatment, promoted GLUD1 protein accumulation