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High levels of ROS damage cellular components including lipids, proteins, and DNA, leading to neuronal dysfunction and death

Quick refresher on free radicals: these can be caused by environmental factors such as pollution, UV radiation, and cigarette smoke, as well as internal factors such as inflammation and metabolism

& Hong, J

Nevertheless, SLC25A40 also transports GSH into the mitochondria and likely plays a secondary but important role

Astrocytes can release functional mitochondrial particles via a calcium- and CD38-dependent manner, which are then taken up by adjacent neurons after stroke, promoting neuronal survival in mice