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Preclinical data show that GLP-1and by extension GLP-1R agonistscan modulate macrophage polarization: in vitro treatment of macrophages with GLP-1 reduced M1-specific markers (e.g., Inducible Nitric Oxide Synthase (iNOS), TNF-, IL-6) and increased M2-associated markers (e.g., IL-10, CD163, CD204) via signaling pathways involving increased signal transducer and activator of transcription 3 (STAT3) activation, thereby promoting an anti-inflammatory M2 phenotype [51]

Dysfunction of the hypothalamus can lead to disturbances in bodily temperature, mood, hunger, growth, sexual development, and sleep patterns

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These medications are often used to help manage type 2 diabetes and obesity, and are commonly offered as injections administered at regular intervals

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