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The resulting histamine overload causes systemic inflammation, leading to classic MCAS symptoms like sudden hives, flushing, severe gastrointestinal distress, rapid heart rate (tachycardia), and sudden intolerances to previously safe foods

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When pentadecapeptide BPC 157 therapy was given in already advanced stage of paracetamol toxicity, such as at 3 hours after initial paracetamol application, only mild liver lesions ( Table 3, Fig

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The mechanism involves actin binding