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The mean HR responses were similar in the three study groups at rest (approximately 61-63 bpm) and in response to the sprint bouts with mean HRs increasing from 150-155 bpm to approximately 170 bpm from the first to fifth sprint bout

[13] [15] Administered as a once-weekly subcutaneous injection, tirzepatide is available in escalating doses from 2.5 mg to 15 mg

However, in some cases, they may be used alongside medication with the advice and supervision of a healthcare professional

The frequency of these events is lower with once-weekly GLP-1RAs compared to once-daily or twice-daily GLP-1RAs (Table 2) [57]