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The fin on the back of her head was originally blonde like her hair, but Kamp Koral changed it to violet, and the change slowly seeped into The Patrick Star Show and the main series

Methylene blue acts as a co-factor for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent methemoglobin reductase, which leads to the formation of reduced methylthioninium chloride that can reduce ferric iron to ferrous iron needed to restore the oxygen-carrying capacity of hemoglobin

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Notably, many protein aggregates also present in neuronal axons, such as mutated TDP-43 and FUS, resulting in abnormal RNA transport and dysregulated protein synthesis (Marrone et al., 2019)