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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper (see DOSAGE AND ADMINISTRATION, and WARNINGS)

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Additionally, another major member of incretins, GIP, and its analogs have also demonstrated neuroprotective effects in disease animal models and can enhance the effects of GLP-1

GLP-1 agonists are medications designed to replicate the effects of a natural hormone in the body called glucagon-like peptide-1

This article will explore the link between Tirzepatidethe active ingredient in Zepboundand gastrointestinal discomfort