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Those with a history of medullary thyroid cancer, thyroid nodules of unknown nature, or multiple endocrine neoplasia syndrome 2 cannot safely use semaglutide due to theoretical thyroid risk

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The potential of GLP1 medications extends beyond diabetes and obesity, as their effectiveness is also recognized in other comorbidities such as cardiovascular and renal diseases, 27 which can bring long-term cost savings and improved public health

In long-term studies, people who came off semaglutide regained about two-thirds of the weight they had lost within a year, and many saw blood sugar, cholesterol, and blood pressure trend back toward where they started

Left untreated, B12 deficiency can cause: Thats why NHS guidelines recommend lifelong supplementation either by injection or oral capsule