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Insulin resistance drives many of the symptoms, including irregular or absent periods, because high insulin levels increase androgens and interfere with ovulation

The amino acid which can produce butyrate from microbial fermentation include glutamate, lysine, histidine, cysteine, serine and methionine (48)

A potential additional advantage of GIP is the protection against hypoglycemia since GIP infusion is accompanied by a decreased need for further glucose administration to maintain a satisfactory glycemic level during an insulin-induced hypoglycemic clamp [15]

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PMID 21658839