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Whereas, hydrophobic small molecules frequently failed on the road toward clinical use, due to variable and complexed problems including bio-availability, and swift clearance, which in turn because of their physicochemical nature

Following an oral dose, NAC absorbs rapidly, reaching its peak plasma concentration within 1 to 2 hours, and has a relatively short terminal half-life of approximately 5.5 to 6.25 hours

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Bibcode:1970Natur.226..938B