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Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)

GAPS recognizes the connection between the functions of the digestive system and the brain

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However, it is important to acknowledge the side effects associated with its use, including nausea, rash, fatigue, restlessness, photosensitivity, acute neuropathy, and even episodes of mania and serotonergic syndrome when used concurrently with other antidepressant drugs