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2018;13:e0209336 Irizarry KJ, Malladi SB, Gao X, Mitsouras K, Melendez L, Burris PA, et al

4.3 Pharmacokinetic parameters in Sprague-Dawley rats after intravenous and intramuscular administration A total of 324 SD rats were randomly divided into five groups, including 66 rats in group one, 60 rats each in groups two to four, and 78 rats in group five, with each group comprising half male and half female subjects

Ethics statement The studies involving humans were approved by The Ethics Committee of Weifang Peoples Hospital

Semaglutide is a selective glucagon-like peptide-1 (GLP-1) receptor agonist that acts in the areas of the brain involved in regulation of appetite and caloric intake and slows gastric emptying