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In this context, such effect biomarkers are recognized as an ideal tool for investigating the relationships between exposure to environmental chemical and adverse health outcomes in population-based studies, as well as for elucidating some of the mechanisms underlying these associations 6,10,24

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The combined effect: a bottle that should be good for 28 days can be unsafe at day 10 if multiple failure modes stack

This highlights the need for a more rigorous clinical approach

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