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As GLP-1 has a very short plasma half-life of ~13 min, it is widely believed that at least some of its anorexic action is mediated through activation of GLP1R located on afferent nerve endings in the vicinity of L-cells

Molagoda et al., 2021

Also, pay attention to other health signs

Administration Methods Semaglutide is administered via subcutaneous injection, meaning it is injected under the skin

This included both participants who had discontinued the study medication during the blinded phase as their appetite and cravings had returned (after unblinding, both participants were confirmed to be randomized to placebo)