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These findings suggest that GHK-Cus anti-inflammatory action is mediated, at least in part, by modulating the p38 MAPK and NF-B signaling pathways

37 Rapamycin and other mTOR inhibitors similarly promote combined autophagy-mitophagy responses, improving mitochondrial integrity and cardiac outcomes in multiple disease models

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While not a targeted microbiome drug, its pleiotropic effects (part immune modulation, part microbe modulation) have been tested in early PD and HD trials (with mixed results)