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In the documented protocol, someone tolerating the compound well and progressing at 7.5 or 10 mg has no requirement to escalate further

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Dig Dis Sci 50:S24S33 Tewari D, Anjum N, Tripathi Y (2014) Phytochemistry and pharmacology of Plantago Ovata : a natural source of laxative medicine

Material and Methods Cell lines Six B-cell precursor (Nalm6, Nalm16, Nalm30, REH, RS4;11, and 697) and 7 T-ALL (ALL-SIL, CCRF-CEM, HPB-ALL, Jurkat, Molt-4, P12-ICHIKAWA and TALL-1) cell lines were used in the study

269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway