Berberine, for example, improves insulin sensitivity through different mechanisms but does not reduce hunger signals or promote sustained weight loss at the scale seen in clinical trials of semaglutide
New technologies based on mRNA and viral vector gene transfer are being developed as potential alternative therapeutic strategies for LAL-D, though these remain investigational (50)
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The mechanism is understood, the outcomes are predictable, and the safety profile at appropriate concentrations is well characterised
The tradeoff is that GLP-1 prescribing within a general telehealth platform is one task among many for providers who are also managing a wide range of other conditions