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Their seemingly miraculous properties have been praised by tech CEOs, podcaster Joe Rogan, and celebrities such as Gwyneth Paltrow, Jennifer Aniston, and Kim Kardashian, who says her daily regimen changed my life. But many doctors are alarmed by a craze that has thousands of people injecting themselves with substances of dubious origin and whose long-term effects are unknown

As estrogen levels decline, women may burn 250300 fewer calories per day, making weight gain easier and weight loss harder

Brief temperature excursions of a few hours are unlikely to cause significant degradation

Results were reportedly positive, but the published data is limited

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