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This table outlines key hormonal conditions and their potential relationship to medication tolerability, supporting more intentional provider conversations about timing and dosage adjustments

Semaglutide patches remain investigational and are not yet FDA-approved for weight management, while injectable semaglutide has robust clinical evidence supporting its efficacy

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346 Future Perspectives This review has attempted to summarise the complexity of the regulation of metabolic homeostasis by discussing the known/speculative actions of the incretin hormones and the metabolic hormones that are produced by the pancreatic islets