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Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein

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A controlled trial that included 30 healthy volunteers with normal hearing found 600 mg lipoic acid daily for 10 days prior to experimental noise exposure reduced temporary noise-induced hearing loss better than a single 600 mg dose of lipoic acid one hour before noise exposure or no lipoic acid

This Trojan horse effect may further amplify toxicity of PET MNPs [166]

Gastroenterology 144 , S732 (2013)