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Specifically, bacterial dipeptidyl peptidase-4 (mDPP4) isoenzymes have been identified as capable of degrading the host active glucagon-like peptide-1 (GLP-1), which leads to the disruption of the integrity of the intestinal barrier and the impaired glucose metabolism in mice

Flint et al

The cargo hold of a plane can experience extreme temperature shifts, and the interior of a car can quickly exceed the 86F safety limit for these drugs