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In clinical trials, the half-life of cagrilintide (0.164.5 mg) ranged from 159 to 195 hours, and the elimination half-life ranged from 7 to 8 days, making cagrilintide suitable for once-weekly dosing

Our findings offer comprehensive real-world evidence for the cardiovascular effectiveness of tirzepatide in clinical practice in the absence of studies with direct comparisons to semaglutide, and ahead of further evidence from the SURPASS-CVOT randomized controlled trial that compared tirzepatide against an older GLP-1 receptor agonist that is not frequently used in routine care 14,17