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Tesofensine Timeline & What to Monitor Because of the 9-day half-life, the appetite-suppression effect builds over the first 4-6 weeks

Reduced anxiety and mood swings

Pernicious anemia occurs more commonly in people who already have diseases that are linked to immune-system abnormalities, such as Graves disease, hypothyroidism (under-functioning thyroid gland), thyroiditis (inflammation of the thyroid), vitiligo, and Addison's disease (adrenocortical insufficiency)

This decrease impairs its physiological functions in learning, memory, motor regulation, and sleep cycle regulation

These are generally most pronounced when starting or increasing doses and tend to diminish over time as the body adjusts