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doi: 10.1038/s41419-022-04924-4 54 LiuTZhaoJLinC

By activating both GIP and GLP-1 receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite

Ultimately, GLP-1based adjunct therapy in type 1 diabetes should be viewed as a personalized option rather than a standard treatment

Our previous studies have demonstrated that sitagliptin may protect diabetic fatty liver by reducing ROS production and NF-B signaling pathway activation [106]