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In human studies, GLP-1 receptor agonists may slightly increase bone formation markers (eg, osteocalcin, bone alkaline phosphatase) and acutely reduce bone resorption markers, but these effects are modest and inconsistent

Funding This study was supported by grants from the National Natural Science Foundation of China (30800011 and 31872621), the State Key Laboratory of Microbial Technology Foundation (M2017-01), the Natural Science Foundation of Shandong Province (ZR2020MC006), People's Republic of China, the Instrument Improvement Funds of Shandong University Public Technology Platform (ts20220104), the State Key Laboratory of Microbial Technology Open Projects Fund (Project No

Some argue that aging is an effect of accumulation of damage to proteins, DNA, and lipids, and others suggest certain genes preprogram aging

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