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assessed the effect of VPA and other antiepileptic drug (OAD) treatments on the plasma carnitine pool in pediatric patients [91]

A., Shapiro, L

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a Japanese single-center, retrospective study

This effect is primarily mediated by an increase in the phosphorylation of insulin receptor substrate 1 (IRS1) and a concomitant inhibition of Akt phosphorylation, a crucial component of the insulin signaling pathway