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How Biomarkers & Genetics Can Inform Your Treatment Strategy Genetic variations in GLP-1 receptor pathways (GLP1R rs6923761), GIPR signaling (GIPR rs1800437), and appetite-control genes (FTO rs9939609, MC4R rs17782313) may provide context for how your body responds to GLP-1 therapies

weight management for specific formulations like Saxenda and Wegovy) Healthcare professionals should remain vigilant for signs of pancreatitis, which is listed as a known adverse effect in the Summary of Product Characteristics (SmPC) for all GLP-1 agents There is no official link established between GLP-1 therapy and pancreatic cancer based on current evidence NICE guidance for type 2 diabetes management (NG28) continues to recommend GLP-1 receptor agonists as appropriate treatment options when specific criteria are met

Nutritional considerations are important, as reduced food intake and gastrointestinal symptoms may affect nutritional status

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