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pylori negative patients ( In addition, a CCK antagonist accelerated the gastric emptying rate which could lead to a benefit in both functional dyspepsia as gastroparesis patients ( Glucagon-Like Peptide 1 (GLP-1) GLP-1, secreted by intestinal endocrine L-cells upon food intake, slows the gastric emptying in diabetes with a decrease in glycemia ( Peptide YY (PYY) PYY is a gut hormone secreted from endocrine L-cells in the gut mucosa, most prominently present in the ileum and the colon, and released into the circulation after ingestion of food ( Serotonin (5-HT) 5-HT is also released by entero-endocrine cells in the gastrointestinal tract, in response to mechanical stimulation or the presence of nutrients or toxins ( 1A agonists enhance gastric accommodation and tend to slow gastric emptying ( Studies focusing on IBS have shown that circulating 5-HT levels rise after a meal, and that this rise is exaggerated in IBS with diarrhea and suppressed in IBS with constipation ( Several 5-HT receptor agonists/antagonists, such as cisapride (5-HT4 agonist, 5-HT2, and 5-HT3 antagonist), tegaserod (5-HT4 and 5-HT1 agonist, 5-HT2a/b antagonist), mosapride (5-HT4 agonist, 5-HT3 antagonist) and revexepride (5-HT4 agonist) have been evaluated for the treatment of dyspepsia and gastroparesis, although not all studies show efficacy (114116)

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