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Among the GLP1-RA agents, once-weekly semaglutide may be especially promising in type 1 diabetes, as this agent has demonstrated superiority over other GLP1-RAs in terms of glycaemic control and weight loss in type 2 diabetes, as well as good tolerability [56]

These and other advances over the past 5 years offer exciting opportunities and daunting challenges for the development of new therapeutic strategies for the treatment of type 2 diabetes

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