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Interestingly, the OB is not only a metabolic sensor but also participates in the control of energy balance: CRISPR gene editing to enhance the excitability of MCs in DIO mice resulted in improved glucose tolerance 34 and these neurons also control the cephalic phase of insulin release 16

The medicine is evolving quickly, having already expanded to include oral treatments with the first-ever FDA approval for a GLP-1 pill for weight loss for Wegovy at the end of 2025

Fill nutrient gaps on GLP-1s GLP-1s reduce appetite, which can make it tough to get all the nutrients your body needs

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