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GLP-1 RAs effectively reduce appetite and caloric intake, yet unstructured reduced dietary intake is often nutrient poor and patients risk losing the fiber, polyphenols, and foods that sustain microbiome diversity, normobiosis, microbial mediators, and intestinal barrier function

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Tanida Y, Matsuura A (2020) Alchemical free energy calculations via metadynamics: application to the theophylline-RNA aptamer complex